The Royal United Hospital (RUH) in Bath is to axe up to 300 posts in the latest round of NHS job cuts, reports the BBC.
The 650-bed hospital, which employs 3,500 staff, must make £13.2m savings.
The trust also plans to reduce costs by discharging patients "as soon as clinically possible" and halting the use of agency staff.
The latest redundancies follow the loss of 1,000 jobs at University Hospital, Stoke-on-Trent and 400 at Surrey and Sussex Healthcare NHS Trust.
The James Paget Hospital, in Gorleston, Norfolk, also announced on Wednesday it is to shed 100 jobs in a bid to reduce its overspend by £4m.
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